Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

2.6K
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
2.6K
Step-Growth Polymerization: Overview01:03

Step-Growth Polymerization: Overview

4.6K
Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
4.6K
Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

3.0K
The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the...
3.0K
Polymer Classification: Stereospecificity01:26

Polymer Classification: Stereospecificity

3.4K
Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ketamine Induces Apoptosis and Inhibits Proliferation in HT-29 Colorectal Cancer Cells.

Biomedicines·2026
Same author

Multi-Target Neuroprotective Compound Exhibits EAAT2-Modulating and Alzheimer's Pathology-Attenuating Effects in In Vitro and In Vivo Models.

ACS chemical neuroscience·2026
Same author

Conformational Analysis of Neutral and Ionic Arginine Forms Using DFT Methods.

ACS omega·2025
Same author

Investigation of interactions of doxorubicin with purine nucleobases by molecular modeling.

Journal of molecular modeling·2022
Same author

Immobilization of α-Glucosidase in Chitosan Coated Polygalacturonic Acid.

Preparative biochemistry & biotechnology·2017
Same author

DFT and TDDFT investigation of the Schiff base formed by tacrine and saccharin.

Journal of molecular modeling·2016

Related Experiment Video

Updated: Mar 20, 2026

Polymer Microarrays for High Throughput Discovery of Biomaterials
13:37

Polymer Microarrays for High Throughput Discovery of Biomaterials

Published on: January 25, 2012

15.1K

Modeling prepolymerization step of a serotonin imprinted polymer.

Ersin Gündeğer1, Cenk Selçuki2, Burcu Okutucu3

  • 1Graduate School of Natural and Applied Science, Biotechnology Program, Ege University, 35100, Bornova, Izmir, Turkey.

Journal of Molecular Modeling
|June 6, 2016
PubMed
Summary

Molecular imprinting creates artificial receptors using synthetic polymers. This study used molecular modeling to show DMSO controls cavity formation in serotonin imprinted polymers via hydrogen bonding and dispersive interactions.

Keywords:
AcrylamideCavityDMSOMolecular imprintingPorogenSerotonin

More Related Videos

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers
10:09

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers

Published on: June 30, 2018

8.7K
Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

8.4K

Related Experiment Videos

Last Updated: Mar 20, 2026

Polymer Microarrays for High Throughput Discovery of Biomaterials
13:37

Polymer Microarrays for High Throughput Discovery of Biomaterials

Published on: January 25, 2012

15.1K
Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers
10:09

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers

Published on: June 30, 2018

8.7K
Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

8.4K

Area of Science:

  • Polymer Chemistry
  • Computational Chemistry
  • Materials Science

Background:

  • Molecular imprinting is a key technique for creating synthetic polymers with specific binding sites.
  • Non-covalent imprinting offers flexibility in monomer selection and target molecule design.
  • Understanding the role of solvents is crucial for optimizing imprinting processes.

Purpose of the Study:

  • To investigate the role of Dimethyl sulfoxide (DMSO) in the formation of serotonin imprinted polymers (MIPs) using computational methods.
  • To elucidate the interactions between the template molecule, functional monomer, and solvent during the non-covalent imprinting process.
  • To provide insights into the cavity formation mechanism in MIP synthesis.

Main Methods:

  • Density Functional Theory (DFT) calculations at the ωB97XD/6-31++G(d,p) level.
  • Polarizable Continuum Model (PCM) for solvent effect calculations.
  • Computational Infrared (IR) spectroscopy to analyze molecular interactions.

Main Results:

  • Computational modeling revealed that DMSO plays a critical role in controlling the size and shape of the polymer cavity.
  • Hydrogen bonding and dispersive interactions between DMSO and other components were identified as key factors in MIP formation.
  • Computational IR spectra clearly indicated specific interaction modes, complementing experimental limitations.

Conclusions:

  • DMSO significantly influences the non-covalent molecular imprinting process for serotonin recognition.
  • The study provides a detailed computational model for the serotonin-acrylamide-DMSO system.
  • This work may pave the way for developing general computational protocols for other molecular imprinting applications.