Related Experiment Video

Updated: Mar 20, 2026

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs
10:32

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs

Published on: December 19, 2019

11.7K

YAP/TAZ as therapeutic targets in cancer

Francesca Zanconato1, Giusy Battilana1, Michelangelo Cordenonsi1

  • 1Department of Molecular Medicine, University of Padua School of Medicine, viale Colombo 3, 35126 Padua, Italy.

Current Opinion in Pharmacology
|June 6, 2016
PubMed

Insights

The study explores the biology of YAP and TAZ transcriptional regulators, highlighting their roles in growth, repair, and cancer. It identifies YAP/TAZ as potential targets for novel anti-cancer drug development.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Cell Signaling

Background:

  • YAP (Yes-associated protein) and TAZ (T-and-zendeficiency) are key transcriptional regulators.
  • These proteins play critical roles in organ development, tissue regeneration, and the progression of cancer.
  • Aberrant YAP/TAZ activation is frequently observed in various carcinomas.

Purpose of the Study:

  • To review the known regulatory mechanisms of YAP and TAZ.
  • To identify potential therapeutic strategies targeting YAP/TAZ for cancer treatment.
  • To explore YAP/TAZ as prime targets for anti-cancer drug design.

Main Methods:

  • Literature review of YAP/TAZ biology and regulation.
  • Analysis of YAP/TAZ involvement in cancer hallmarks.
  • Identification of regulatory pathways amenable to therapeutic intervention.

Main Results:

  • YAP/TAZ are central to fundamental biological processes including growth and repair.
  • Constitutive YAP/TAZ activation is a common feature in many cancers.
  • YAP/TAZ signaling contributes to multiple hallmarks of cancer.

Conclusions:

  • Understanding YAP/TAZ regulation provides insights into cancer development.
  • Targeting YAP/TAZ pathways presents a promising strategy for novel anti-cancer therapies.
  • Further research into YAP/TAZ modulation could lead to effective cancer treatments.

More Related Videos

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

7.5K
All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System09:55

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System

Published on: December 20, 2021

3.5K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.7K
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
65
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.6K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K