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PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
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PLA micro- and nano-particles.

Byung Kook Lee1, Yeonhee Yun1, Kinam Park1

  • 1Departments of Biomedical Engineering & Pharmaceutics, Purdue University, West Lafayette, Indiana, USA.

Advanced Drug Delivery Reviews
|June 6, 2016
PubMed
Summary

Poly(d,l-lactic acid) (PLA) micro- and nanoparticles are versatile for drug delivery. Despite challenges like low drug loading, ongoing innovations promise clinically useful formulations.

Keywords:
Drug delivery systemFabrication methodsMicro-particlesNano-particlesPLA

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Poly(d,l-lactic acid) (PLA) is widely utilized in biomedical applications due to its biodegradability, biocompatibility, and non-toxicity.
  • PLA micro- and nanoparticles serve as effective controlled drug delivery systems for various therapeutic molecules.
  • Common formulation methods include emulsion, salting out, and precipitation.

Purpose of the Study:

  • To review the applications of PLA micro- and nanoparticles in drug delivery.
  • To discuss the methods used for formulating PLA particles.
  • To highlight the challenges and future directions in PLA-based drug delivery systems.

Main Methods:

  • Literature review of PLA particle formulation techniques.
  • Analysis of PLA's properties relevant to drug delivery.
  • Discussion of challenges and innovations in PLA particulate formulations.

Main Results:

  • PLA particles are effective for delivering proteins, genes, vaccines, and anticancer drugs.
  • Formulation methods like emulsion, salting out, and precipitation are employed to optimize PLA particles.
  • Key challenges include low drug loading capacity, low encapsulation efficiency, and terminal sterilization.

Conclusions:

  • PLA micro- and nanoparticles show significant promise for controlled drug delivery.
  • Overcoming current limitations through continuous innovation is crucial for clinical translation.
  • Further advancements in particulate formulation will enhance the utility of PLA in medicine.