Related Experiment Video
Updated: Mar 20, 2026
08:50
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
24.5K
[Bile salt nephropathy/cholemic nephrosis].
Maxime Leclerc1, Antoine Lanot1, Clémence Béchade1
1Service de néphrologie, dialyse et transplantation, CUMR, CHU de Caen, avenue de la Côte-de-Nacre, 14033 Caen cedex 9, France.
Nephrologie & Therapeutique
|June 6, 2016
Summary
Bile cast nephropathy, a kidney disease linked to cholestatic jaundice, can cause acute kidney injury. This case highlights the diagnostic challenges and histological evidence of this under-recognized condition.
Area of Science:
- Nephrology
- Hepatology
- Pathology
Background:
- Bile cast nephropathy is a tubulo-interstitial nephropathy associated with cholestatic jaundice and hyperbilirubinemia.
- Diagnosis can be challenging due to under-estimation and difficulties in obtaining renal biopsies.
- Bile salts, filtered by glomeruli, can form casts leading to acute tubular necrosis.
Observation:
- The study presents a case of drug-induced hepatic jaundice complicated by acute kidney failure.
- The kidney failure was secondary to bile cast nephropathy.
- Histological evidence confirmed the diagnosis.
Findings:
- Bile cast nephropathy is a significant cause of acute kidney injury in patients with cholestasis.
- Histological examination is crucial for diagnosing bile cast nephropathy.
- Hemostatic abnormalities in patients with liver injury can complicate renal biopsy procedures.
Implications:
- Increased awareness and diagnostic vigilance for bile cast nephropathy are needed.
- Understanding the pathogenesis is key for developing targeted treatments.
- Supportive and etiological treatments are essential for managing this condition.
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
852
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
852
01:24Nephrotic Syndrome III : Nursing Management
421
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
421
01:26Nephrotic Syndrome II : Assessment and Medical Management
300
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
300
01:19Bile
5.5K
Bile is a crucial bodily fluid, characterized by its yellow-green color and alkaline nature. Produced in the liver, it is transported through the common hepatic duct into either the cystic duct, leading to the gallbladder, or directly into the common bile duct. The flow of bile is regulated by the sphincter of Oddi located at the entrance of the duodenum. When this sphincter is closed, bile is redirected to the gallbladder for storage and concentration.
Bile is released when dietary fats enter...
Bile is released when dietary fats enter...
5.5K
01:10Nephrons
8.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
8.3K
01:25Chronic Kidney Disease I: Introduction
1000
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1000