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Neuralgic amyotrophy of Parsonage and Turner. Which nerves are most frequently involved in daily practice? Data from 355 patients.

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Related Experiment Video

Updated: Mar 20, 2026

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury
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Neuralgic amyotrophy. An update.

Paul Seror1

  • 1Laboratoire d'électroneuromyographie, 146, avenue Ledru-Rollin, 75011 Paris, France.

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|June 7, 2016
PubMed
Summary

Neuralgic amyotrophy (NA) is a painful nerve condition with unknown causes, often affecting the brachial plexus. Early corticosteroid treatment may improve pain and recovery, though some cases result in persistent disability.

Area of Science:

  • Neurology
  • Immunology

Background:

  • Neuralgic amyotrophy (NA), also known as Parsonage-Turner syndrome, is a rare neurological disorder characterized by acute, severe pain and subsequent muscle weakness.
  • Despite being described a century ago, the exact pathophysiology of NA remains elusive, though an inflammatory or autoimmune basis is suspected.

Purpose of the Study:

  • To summarize the clinical presentation, diagnostic features, and treatment outcomes of neuralgic amyotrophy.
  • To differentiate between idiopathic and hereditary forms of NA and their respective prognoses.

Main Methods:

  • Review of clinical characteristics, electrodiagnostic findings, and treatment responses in NA patients.
  • Analysis of genetic factors, particularly mutations in the SEPT9 gene, associated with hereditary NA.
Keywords:
Neuralgic amyotrophyParsonage and Turner syndromePlexopathy

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Main Results:

  • NA typically presents as asymmetric mononeuropathy affecting the upper brachial plexus, with severe axonal damage evident electrodiagnostically.
  • Eighty percent of patients experience good recovery within 3 years, but 20% of idiopathic cases and a higher proportion of hereditary cases face persistent disability, recurrences, and atypical nerve involvement.
  • Early corticosteroid treatment appears to alleviate pain and potentially shorten recovery time.

Conclusions:

  • Neuralgic amyotrophy is a distinct clinical entity with significant morbidity, necessitating further research into its underlying mechanisms.
  • Distinguishing between idiopathic and hereditary forms is crucial for prognosis and management, with genetic factors like SEPT9 mutations playing a role in the latter.