[Regional blood flow and air level in the lung segments in recurrent and chronic bronchitis in children]
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This study used transbronchial regional electroplethysmography to assess blood flow and air content in children with chronic bronchitis and bronchiectasis. Findings reveal altered regional blood flow and air content in affected lung segments, varying by disease severity and deformity.
Area of Science:
- Pediatric Pulmonology
- Medical Imaging
- Respiratory Physiology
Background:
- Chronic bronchitis and bronchiectasis are significant respiratory conditions in children.
- Understanding regional lung function is crucial for diagnosing and managing these diseases.
- Transbronchial regional electroplethysmography offers a method to assess localized lung blood flow and air content.
Purpose of the Study:
- To evaluate regional blood flow and air content in children with chronic bronchitis and bronchiectasis using transbronchial regional electroplethysmography.
- To compare these parameters in children with different forms of chronic bronchitis (deforming vs. non-deforming) and bronchiectasis.
- To investigate the relationship between bronchial deformity and regional lung function alterations.
Main Methods:
- Transbronchial regional electroplethysmography was performed on 67 children (aged 3-15 years).
- Participants included 44 children with chronic bronchitis and 23 with bronchiectasis.
- A control group of children with recurrent bronchitis in an inactive phase was included for comparison.
Main Results:
- Children with chronic bronchitis without bronchial deformity showed normal regional blood flow compared to controls.
- Diffuse deforming bronchitis was associated with reduced blood flow in posterobasal lung segments.
- Local deformities and bronchiectasis led to decreased air content and blood flow in affected areas, with increased blood flow in adjacent regions.
Conclusions:
- Regional blood flow and air content are altered in pediatric chronic bronchitis and bronchiectasis, particularly with bronchial deformity.
- The pattern of alteration varies depending on the type and extent of the disease.
- Increased blood flow in adjacent areas may indicate an irritative response to the lesion focus.
Abstract:
Transbronchial regional electroplethysmography was employed to measure the blood flow and air content in 67 children aged 3-15 years. Of these, 44 children suffered from chronic bronchitis and 23 from bronchiectasis. Children with recurrent bronchitis examined during the inactive phase of the disease marked by clinicoendoscopic silence were used as controls. In children with chronic bronchitis who escaped bronchial deformity, the levels of the regional blood flow were similar to those seen in the controls. Meanwhile in diffuse deforming bronchitis the reduction of the blood flow was noted in the posterobasal segments on both sides. In local deformities and bronchiectasis the levels of the air content and blood flow were decreased in the affected area whereas in the adjacent part the blood flow was more intense as compared with the symmetrical part on the opposite side, which was likely to be connected with the irritative effect of the focus of lesion.