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Hodgkin's Disease: Results of a Single Center in Central Anatolia
Insights
This study evaluated 119 Hodgkin
Area of Science:
- Oncology
- Hematology
- Clinical Medicine
Background:
- Hodgkin's Disease (HD) represents approximately 1% of all new cancer diagnoses.
- Understanding the demographics, staging, and treatment outcomes of HD is crucial for improving patient care.
Purpose of the Study:
- To analyze the clinical characteristics, treatment modalities, and survival rates of Hodgkin's Disease patients.
- To evaluate the efficacy of cyclophosphamide, vincristine, procarbazine, and prednisolone (COPP) chemotherapy in HD management.
Main Methods:
- Retrospective analysis of 119 Hodgkin's Disease cases treated at Erciyes University Hospital.
- Evaluation of patient demographics, disease stage (Rye classification), histological subtypes, treatment regimens, and patient outcomes (remission, progression, survival).
Main Results:
- The study included 119 patients, with a male predominance (67.2%).
- Complete remission was achieved in 84.9% of patients treated with COPP chemotherapy.
- A significant difference in five-year survival rates was observed between early (stage I-II, 90.1%) and advanced (stage III-IV, 55.3%) disease stages (p=0.03).
Conclusions:
- Combination chemotherapy (COPP) demonstrates high efficacy in achieving remission for Hodgkin's Disease.
- Early-stage Hodgkin's Disease patients exhibit significantly better survival rates compared to those with advanced-stage disease.
- The findings underscore the importance of timely diagnosis and treatment for improving Hodgkin's Disease prognosis.
Abstract:
Hodgkin's Disease (HD) accounts for about 1% of newly diagnosed malignant diseases. In this study 119 HD cases followed in Erciyes University Hospital were evaluated. 67.2% of the patients was male, 32.8% female. The patients' age ranged from 15 to 72 years with a median of 41.5 years. Of the patients 10.1% was stage I, 29.4% stage II, 39.5% stage III, and 21.0% stage IV. According to Rye classification frequency of histologic subtypes was as follows; 21.0% lymphocyte predominant, 25.2% nodular sclerosis, 43.7% mixed cellularity, and 10.1% lymphocyte depletion. Combination chemotherapy consisting cyclophosphamide, vincristine, procarbazine and prednisolone (COPP) was used as first line treatment in 59.7% of patients. Complete remission was achieved in 84.9% of patients and partial remission in 5.0% of patients; response could not be obtained in remaining 10.1% of patients. Disease progression or recurrence was observed in 30.2% of patients. Five year survival rate was found as 70.8% of all patients, 90.1% for stage I-II, 55.3% for stage III-IV patients (p= 0.03).
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