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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Introduction to Hemostasis01:05

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
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Blood Transfusion and Agglutination02:45

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
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A Material Conferring Hemocompatibility.

William Everett1, David J Scurr2, Anna Rammou1

  • 1Centre for Nanotechnology &Regenerative Medicine, University College London, London, UK.

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|June 7, 2016
PubMed
Summary
This summary is machine-generated.

This study explores L-Arginine methyl ester (L-AME) functionalized polyurethane for blood-contacting devices. The novel biomaterial enhances endothelial progenitor cell viability and shows anti-thrombogenic properties.

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Area of Science:

  • Biomaterials Science
  • Medical Device Engineering
  • Cardiovascular Research

Background:

  • Maintaining blood-contacting device patency requires functional endothelium.
  • Poly(carbonate-urea) urethane (PCU) is a common base material.
  • Biomimetic functionalization is needed for improved blood compatibility.

Purpose of the Study:

  • To investigate the feasibility of L-Arginine methyl ester (L-AME) functionalized PCU for blood-contacting applications.
  • To assess the in-vitro anti-thrombogenic properties of L-AME within a polyurethane matrix.
  • To evaluate the effect of L-AME on endothelial progenitor cell (EPC) viability.

Main Methods:

  • Functionalization of PCU with L-Arginine methyl ester (L-AME).
  • In-vitro cell culture of EPCs on L-AME functionalized PCU.
  • Assessment of L-AME's interaction with endothelial nitric oxide synthase (eNOS) in blood.
  • Evaluation of anti-thrombogenic properties of L-AME in solution and within the polymer.

Main Results:

  • Successful culturing of EPCs on L-AME functionalized material, indicating increased cell viability.
  • Demonstration of L-AME's potential as a bioactive porogen releasing upon blood contact.
  • Evidence of novel anti-thrombogenic properties of L-AME in both solution and polymer-bound forms.
  • L-AME incorporation into PCU shows promise for blood-contacting medical devices.

Conclusions:

  • L-AME functionalized PCU is a promising biomaterial for blood-contacting devices.
  • The material supports endothelial progenitor cell viability and exhibits anti-thrombogenic effects.
  • L-AME offers potential for endogenous nitric oxide up-regulation in medical applications and wound healing.