Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mutations01:35

Mutations

45.4K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
45.4K
Mutations01:39

Mutations

95.9K
Overview
95.9K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

5.6K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.6K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

41.8K
Overview
41.8K
Biological Effects of Radiation02:59

Biological Effects of Radiation

19.4K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
19.4K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contact-dependent regulation of UV-B/C-induced cell fate by neighboring intact cells.

Journal of photochemistry and photobiology. B, Biology·2026
Same author

Oxidative protein damage negatively affects protein-protein interaction: The case of KRAS-cRAF.

Biochemical and biophysical research communications·2024
Same author

Beyond the genome: protecting the proteome may be the key to preventing skin aging.

European journal of dermatology : EJD·2024
Same author

Corrigendum to "Toxicity of the spike protein of COVID-19 is a redox shift phenomenon: A novel therapeutic approach" [Free Radical Biology and Medicine 206 (2023) 106-110].

Free radical biology & medicine·2023
Same author

Toxicity of the spike protein of COVID-19 is a redox shift phenomenon: A novel therapeutic approach.

Free radical biology & medicine·2023
Same author

Functionalized Au<sub>15</sub> nanoclusters as luminescent probes for protein carbonylation detection.

Communications chemistry·2023

Related Experiment Video

Updated: Mar 20, 2026

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
11:24

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation

Published on: July 3, 2015

11.6K

Protein damage, radiation sensitivity and aging.

Miroslav Radman1

  • 1Mediterranean Institute for Life Sciences (MedILS), 21000 Split, Croatia; Inserm Unit 1001, Université Paris-Descartes, Sorbonne Paris Cité, Faculté de Médecine Paris Descartes, 75014 Paris, France.

DNA Repair
|June 7, 2016
PubMed
Summary
This summary is machine-generated.

Protein damage, not DNA damage, is key to radiation resistance and cell recovery. This proteome protection is crucial for survival, aging, and age-related diseases.

Keywords:
Age-related diseasesAgingDNA repairIonizing and UV irradiationProtein oxidationReactive oxygen species

More Related Videos

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
07:08

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

Published on: August 31, 2022

2.1K
Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells
08:18

Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells

Published on: September 5, 2017

10.4K

Related Experiment Videos

Last Updated: Mar 20, 2026

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
11:24

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation

Published on: July 3, 2015

11.6K
Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
07:08

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

Published on: August 31, 2022

2.1K
Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells
08:18

Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells

Published on: September 5, 2017

10.4K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Gerontology

Background:

  • Cellular recovery from radiation damage is often attributed to DNA repair mechanisms.
  • However, the role of protein integrity in radiation resistance and aging remains underexplored.

Purpose of the Study:

  • To propose that protein damage, rather than DNA damage, is the primary determinant of radiation resistance.
  • To investigate the link between proteome protection, cellular recovery, aging, and age-related diseases.

Main Methods:

  • Comparative analysis of radiation resistance in various species.
  • Correlation of cell death with protein versus DNA damage levels.
  • Examination of oxidative damage effects on cellular phenotypes.

Main Results:

  • Cell death after radiation exposure correlates with protein damage, not DNA damage.
  • Sufficient residual proteome activity is essential for initiating DNA damage response and repair.
  • Exceptional radiation and desiccation resistance in certain species is linked to superior proteome protection.

Conclusions:

  • Proteome integrity, not genome integrity, is the critical factor for cell survival and recovery post-irradiation.
  • Aging and age-related diseases may arise from the accumulation of age-dependent proteome damage patterns.
  • Targeted proteome protection strategies could be key to enhancing radiation resistance and mitigating aging processes.