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Association between chronic idiopathic urticaria and hypertension: A population-based retrospective cohort study

Heng-Wei Chang1, Hui-Man Cheng2, Hung-Rong Yen3

  • 1Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|June 7, 2016
PubMed

Insights

Patients with chronic idiopathic urticaria (CIU) face a significantly higher risk of developing hypertension later in life. This study highlights a crucial link between CIU and future cardiovascular health concerns.

Area of Science:

  • Dermatology
  • Cardiology
  • Epidemiology

Background:

  • Chronic idiopathic urticaria (CIU) is a condition of unknown cause, characterized by hives without identifiable external triggers.
  • Previous research explored a potential link between hypertension and the duration of CIU.

Purpose of the Study:

  • To investigate the association between chronic idiopathic urticaria (CIU) and the subsequent development of hypertension.
  • To determine if CIU is a risk factor for future hypertension.

Main Methods:

  • A population-based retrospective cohort study utilized Taiwan's National Health Insurance database.
  • Included 2,460 patients with CIU and 9,840 matched controls.
  • Follow-up periods averaged over 7 years for both cohorts.

Main Results:

  • The CIU cohort exhibited a 1.37-fold increased risk of developing hypertension compared to the non-CIU cohort.
  • This association remained significant after adjusting for sex, age, comorbidities, and antihistamine use.

Conclusions:

  • Chronic idiopathic urticaria (CIU) is linked to an elevated risk of future hypertension.
  • Further prospective studies are needed to elucidate the underlying pathophysiologic mechanisms connecting CIU and hypertension.
Abstract

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