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Heparin centenary - an ever-young life-saving drug
Giangiacomo Torri1, Annamaria Naggi2
1Carbohydrate Sciences Department and NMR Centre, Ronzoni Institute, Milan, Italy.
International Journal of Cardiology
|June 7, 2016
Summary
This review celebrates heparin's centenary, exploring its history, structure, and diverse applications. Future research highlights non-anticoagulant therapies, including potential anti-cancer uses and improved pharmaceutical analysis.
Area of Science:
- Biochemistry
- Pharmacology
- Cardiology
Background:
- This collection reviews heparin's historical development and current research on its 100th anniversary.
- It covers structural analysis, biochemical/biological research, and clinical applications.
Discussion:
- Recent technological advances improve the monitoring of pharmaceutical heparin purity and source verification.
- Heparin's efficacy in patients with impaired renal function and the evolution of low molecular weight heparin are discussed.
Key Insights:
- Heparin derivatives show promise in non-anticoagulant therapies, particularly as anti-cancer agents.
- New analytical methods enhance the detection of impurities and animal sources in pharmaceutical heparin.
Outlook:
- Future research will focus on novel non-anticoagulant applications of heparin and its derivatives.
- Continued investigation into heparin's role in patients with renal impairment is essential.
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