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En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
Published on: February 25, 2016
The levels of nitric oxide in beta-thalassemia minor
Nihayet Bayraktar, Mehmet Ali Erkurt1, İsmet Aydoğdu
1Department of Hematology ‹nönü University, Faculty of Medicine Turgut Özal Medical Center 44069 Malatya, Turkey, Phone: +90 505 649 57 05 Fax: +90 422 341 07 28
Objective:
The aim of this study was to investigate the relationship between NO (nitric oxide) and beta-thalassemia minor.
Methods:
A total of 60 patients with beta-thalassemia minor (30 M, 30 F) were included in the study. The control group consisted of 60 healthy subjects (30 M, 30 F). Plasma nitrite/nitrate levels were measured using the Griess reaction method and analyzed by spectrophotometry at 545 nm.
Results:
Plasma direct nitrite, total nitrite and nitrate levels were 7.561±6.19, 42.548±7.37 and 34.84±6.24 in beta-thalassemia minor patients versus 36.9±19.8, 85.9±35.3 and 48.61±17.35 Ìmol/dl in controls, respectively. Plasma direct nitrite, total nitrite and nitrate levels were significantly lower in beta-thalassemia minor patients compared with the control group (p<0.001).
Conclusion:
These findings confirm that plasma NO levels in beta-thalassemia minor patients are decreased at the time of diagnosis. This may be helpful in assessing the prognosis and follow-up evaluation of patients with beta-thalassemia minor.
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