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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
9.7K
Cutaneous tumors in pregnancy
Joanna L Walker1, Annie R Wang1, George Kroumpouzos1
1Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
Clinics in Dermatology
|June 7, 2016
Summary
Pregnancy can affect skin tumors, but moles typically return to normal without increased cancer risk. Pregnancy-associated melanoma outcomes are similar to non-pregnancy cases, though more research is needed for advanced stages.
Area of Science:
- Dermatology
- Oncology
- Obstetrics
Background:
- Pregnancy influences the behavior of various skin tumors.
- Changes in melanocytic nevi during pregnancy are generally temporary.
- Limited data exist on advanced pregnancy-associated melanoma.
Purpose of the Study:
- To review the impact of pregnancy on skin tumors.
- To assess risks and outcomes of pregnancy-associated skin cancers.
- To provide insights into managing these conditions during gestation.
Main Methods:
- Literature review of studies on pregnancy and skin neoplasms.
- Analysis of dermatoscopic features for pigmented lesions.
- Evaluation of outcomes for pregnancy-associated melanoma and other tumors.
Main Results:
- Melanocytic nevi changes are transient; no increased malignancy risk in pregnancy.
- Pregnancy-associated melanoma outcomes are comparable to non-pregnancy cases, but data for advanced stages are limited.
- Increased frequency of vascular tumors like pyogenic granuloma (granuloma gravidarum) observed.
- Dermatofibrosarcoma protuberans shows a more aggressive course during pregnancy.
Conclusions:
- Pregnancy-associated skin tumor behavior varies; vigilance is key.
- Prompt treatment and monitoring are crucial for aggressive tumors like dermatofibrosarcoma protuberans.
- Further research is needed for advanced pregnancy-associated melanoma management and prognostication.
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