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Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
Published on: October 10, 2025
Skin infections in pregnancy
Robert R Müllegger1, Nina S Häring2, Martin Glatz3
1Department of Dermatology, State Hospital Wiener Neustadt, Corvinusring 3-5, 2700 Wiener Neustadt, Austria.
Pregnancy infections, including viral, fungal, bacterial, and parasitic types, can impact maternal immunity and pose risks to offspring. This review details their management and treatment options.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Maternal-Fetal Medicine
Background:
- Pregnancy can alter maternal cellular immunity, affecting infectious disease presentation and course.
- Infections during pregnancy pose significant risks to both mother and fetus, including congenital malformations.
Purpose of the Study:
- To review the clinical presentation, management, and risks of specific infections in pregnancy.
- To critically evaluate treatment options for selected maternal infections.
Main Methods:
- Literature review focusing on viral, fungal, bacterial, and parasitic infections during gestation.
- Analysis of clinical presentation, maternal/fetal risks, and treatment efficacy.
Main Results:
- Detailed review of varicella-zoster virus, condylomata acuminata, Candida vulvovaginitis, Lyme borreliosis, and scabies in pregnancy.
- First-line treatments identified: acyclovir, surgical modalities, clotrimazole/fluconazole, amoxicillin/cefuroxime, and permethrin.
- Synopsis of risks associated with other significant infections during pregnancy.
Conclusions:
- Effective management and timely treatment of infections are crucial during pregnancy.
- Understanding specific pathogen risks and appropriate therapies minimizes adverse maternal and fetal outcomes.
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