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Polymorphic eruption of pregnancy.

Drew Taylor1, Eden Pappo1, Iris K Aronson1

  • 1Department of Dermatology, University of Illinois at Chicago College of Medicine, Chicago, Illinois.

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|June 7, 2016
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Summary
This summary is machine-generated.

Polymorphic eruption of pregnancy (PEP) is a common, benign skin condition during pregnancy, typically appearing in the third trimester. It resolves after delivery, posing no risk to mother or baby, with treatment focusing on symptom relief.

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Area of Science:

  • Dermatology
  • Obstetrics
  • Pregnancy-related dermatoses

Background:

  • Polymorphic eruption of pregnancy (PEP), also known as pruritic urticarial papules and plaques of pregnancy (PUPPP), is a specific dermatosis of pregnancy.
  • It is a benign, self-limited skin disorder with characteristic clinical features.

Purpose of the Study:

  • To review the key features, diagnosis, pathogenesis, and management of polymorphic eruption of pregnancy.
  • To differentiate PEP from other pregnancy dermatoses like pemphigoid gestationis.

Main Methods:

  • Review of clinical features for diagnosis.
  • Discussion of histopathology and immunofluorescence studies for differential diagnosis.
  • Exploration of current theories on PEP pathogenesis.

Main Results:

  • PEP commonly affects primigravidas, appearing in the third trimester.
  • The condition typically resolves near delivery and is associated with multiple gestation.
  • Clinical presentation is key for diagnosis, as histopathology is nonspecific.

Conclusions:

  • Polymorphic eruption of pregnancy is a benign condition with no associated maternal or fetal risks.
  • Diagnosis relies on clinical presentation, with immunofluorescence aiding differentiation from pemphigoid gestationis.
  • Treatment for PEP is primarily symptomatic.