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Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
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Nanoparticles in practice for molecular-imaging applications: An overview.

Parasuraman Padmanabhan1, Ajay Kumar2, Sundramurthy Kumar1

  • 1Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Singapore 636921, Singapore.

Acta Biomaterialia
|June 7, 2016
PubMed
Summary

Multifunctional nanoparticles offer advanced capabilities for early disease detection through molecular imaging. These agents are crucial for developing next-generation diagnostics and therapeutics.

Keywords:
Imaging instrumentationMultifunctional nanoparticlesMultimodal molecular imagingNanoparticles targeted disease

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Area of Science:

  • Nanotechnology and Materials Science
  • Biomedical Engineering
  • Molecular Imaging

Background:

  • Nanoparticles (NPs) are increasingly vital in multimodal and multifunctional molecular imaging.
  • Agents like Superparamagnetic iron oxide (SPIO), manganese oxide (MnO), gold NPs, and quantum dots (QDs) offer unique properties for imaging and therapy.
  • Multifunctional nanoparticles (MNPs) can be engineered for targeted imaging across various modalities.

Purpose of the Study:

  • To review recent advancements in nanomaterials for multimodal and multifunctional molecular imaging.
  • To highlight the distinctive characteristics of nanomaterials suitable for biomedical imaging, therapy, and drug delivery.
  • To provide insights into nanotechnology-related work for planning and understanding.

Main Methods:

  • Review of pertinent literature on nanomaterials in molecular imaging.
  • Discussion of various nanoparticle types and their imaging properties (paramagnetism, SPR, photoluminescence).
  • Exploration of nanoparticle functionalization for targeted applications.

Main Results:

  • Nanoparticles exhibit nanomolar to micromolar sensitivity for detection via imaging instrumentation.
  • Engineered MNPs enable targeted imaging using MRI, SPECT, PET, CT, PAI, fluorescence, and ultrasound.
  • First-generation NPs have been tested in vivo and some are in clinical use.

Conclusions:

  • Nanoparticles are essential for advancing molecular imaging towards multimodality and multifunctionality.
  • Future molecular imaging will enable early detection of diseases like cancer and neurodegenerative disorders.
  • Continued research in NP design and application is crucial for improving diagnostics and therapeutics.