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Updated: Mar 20, 2026
Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
Published on: October 3, 2018
Hyperfibrotic myelodysplastic syndrome: a report of three cases from north India
Prasenjit Das1, Deepali Jain, Reena Das
1R,8/2, Ramesh Park, Laxmi Nagar 110092 Delhi - India,
Abstract:
Extensive fibrosis in myelodysplastic syndromes (MDS) is distinctly infrequent. Herein, we report three rare cases of hyperfibrotic MDS. This entity should be classified separately in the chronic myeloproliferative disease (CMPD)-MDS group due to variable clinical presentation and poor prognosis.
Insights
Extensive fibrosis is rare in myelodysplastic syndromes (MDS). This report details three unique cases of hyperfibrotic MDS, suggesting it warrants separate classification due to its distinct presentation and poor prognosis.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders.
- Extensive bone marrow fibrosis is an uncommon finding in MDS.
- Hyperfibrotic MDS presents a distinct subtype with unique pathological features.
Purpose of the Study:
- To report and characterize rare cases of hyperfibrotic myelodysplastic syndromes.
- To discuss the implications of hyperfibrotic MDS classification.
- To highlight the clinical significance and prognostic implications of this rare MDS subtype.
Main Methods:
- Case series reporting.
- Review of clinical data and bone marrow pathology.
- Differential diagnosis considerations within myeloid neoplasms.
Main Results:
- Three cases of hyperfibrotic MDS were identified.
- These cases exhibited distinct clinical and pathological characteristics.
- Variable clinical presentations were observed across the reported cases.
Conclusions:
- Hyperfibrotic MDS is a rare entity that requires recognition.
- This subtype may necessitate separate classification within myeloid neoplasms.
- Hyperfibrotic MDS is associated with a poor prognosis, underscoring the need for further research and tailored management strategies.
