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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Primary Musculoskeletal Lymphoma.

Mark D Murphey1, Mark J Kransdorf2

  • 1American Institute for Radiologic Pathology (AIRP), 1010 Wayne Avenue, Suite 320, Silver Spring, MD 20910, USA.

Radiologic Clinics of North America
|June 7, 2016
PubMed
Summary
This summary is machine-generated.

Primary bone and soft tissue lymphoma, typically B-cell in origin, presents as aggressive bone destruction with soft tissue extension. MR imaging is crucial for visualizing these rare tumors and their subtle cortical breaches.

Keywords:
B-cell lymphomaExtranodal lymphomaPrimary bone lymphomaPrimary soft tissue lymphoma

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Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • Primary lymphoma of bone and soft tissue is a rare malignancy.
  • These tumors are almost exclusively of B-cell origin.
  • Osseous lymphoma characteristically exhibits aggressive bone destruction and soft tissue invasion.

Purpose of the Study:

  • To describe the imaging characteristics of primary bone and soft tissue lymphoma.
  • To highlight the role of MR imaging in evaluating soft tissue involvement.
  • To differentiate patterns of lymphoma in deep versus superficial soft tissues.

Main Methods:

  • Review of imaging findings in pathologically confirmed cases of primary bone and soft tissue lymphoma.
  • Emphasis on Magnetic Resonance (MR) imaging features.
  • Correlation of imaging findings with tumor location (osseous, deep soft tissue, cutaneous/subcutaneous).

Main Results:

  • MR imaging optimally depicts soft tissue extension of osseous lymphoma.
  • Subtle cortical destruction may indicate intraosseous and soft tissue component communication.
  • Deep soft tissue lymphoma typically appears as intramuscular or intermuscular tumor.
  • Cutaneous or subcutaneous lymphoma presents as nodules or plaquelike thickening.

Conclusions:

  • MR imaging is essential for the comprehensive evaluation of primary bone and soft tissue lymphoma.
  • Characteristic imaging patterns aid in differentiating tumor location and extent.
  • Understanding these patterns improves diagnosis and management planning for this rare entity.