Ni-Catalyzed Amination Reactions: An Overview
Mario Marín1, Raquel J Rama1, M Carmen Nicasio1
1Departamento de Química Inorgánica, Universidad de Sevilla, Aptdo 1203, 41071, Sevilla, Spain.
Chemical Record (New York, N.Y.)
|June 7, 2016
Summary
Nickel-catalyzed amination offers a cost-effective alternative to palladium for forming crucial carbon-nitrogen bonds. This review highlights recent advances in nickel catalysis for synthesizing valuable nitrogen-containing organic compounds.
Area of Science:
- Organic Chemistry
- Catalysis
- Materials Science
Background:
- Nitrogen-containing organic compounds are vital in science and industry.
- Palladium-catalyzed amination is the standard for C(sp(2))-N bond formation.
- The high cost of palladium catalysts limits large-scale applications.
Purpose of the Study:
- To review the development of nickel-catalyzed amination reactions.
- To highlight recent advances and key developments in Ni-catalyzed amination.
- To present nickel as a cost-effective alternative to palladium.
Main Methods:
- Literature review of nickel-catalyzed amination reactions.
- Focus on recent advancements and relevant studies.
- Emphasis on the application of nickel catalysts in C-N bond formation.
Main Results:
- Nickel catalysis is emerging as a viable alternative to palladium.
- Significant progress has been made in Ni-catalyzed amination methodologies.
- Nickel offers a more economical and abundant catalytic option.
Conclusions:
- Nickel-catalyzed amination is a rapidly developing field.
- This approach provides a sustainable and scalable route to nitrogen-containing compounds.
- Further research in Ni-catalyzed amination is crucial for industrial applications.
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