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P50 Sensory Gating in Infants
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Low-level prenatal lead exposure and infant sensory function.

Monica K Silver1, Xiaoqing Li2, Yuhe Liu3

  • 1Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.

Environmental Health : a Global Access Science Source
|June 9, 2016
PubMed
Summary

Prenatal lead exposure, even at low levels, can delay infant sensory development. Higher maternal lead levels in late pregnancy were linked to delayed auditory brainstem response (ABR) and reduced visual acuity (VA) in newborns.

Keywords:
Auditory processingInfantsLeadNeonatesVisual acuity

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Area of Science:

  • Environmental Health
  • Neuroscience
  • Pediatrics

Background:

  • Lead is a known neurotoxicant affecting child development.
  • The impact of lead on infant sensory function is not well understood.

Purpose of the Study:

  • To investigate the effects of prenatal lead exposure on infant sensory function.
  • To assess auditory brainstem response (ABR) and grating visual acuity (VA) in relation to maternal lead levels.

Main Methods:

  • Maternal blood lead levels were measured during pregnancy and cord blood was collected.
  • Newborn ABR and 6-week visual acuity (VA) were assessed.
  • Multivariate regression analyzed the association between lead levels and sensory outcomes.

Main Results:

  • Higher late-pregnancy lead levels correlated with increased ABR central-to-peripheral (C-P) ratios, indicating delayed auditory processing.
  • Elevated maternal lead levels were associated with lower grating visual acuity (VA) in infants.
  • These effects were observed even at relatively low lead exposure levels.

Conclusions:

  • Prenatal lead exposure appears to delay the maturation of auditory and visual systems in infants.
  • Findings suggest low-level lead exposure impacts sensory system myelination.
  • Early-pregnancy lead exposure effects on sensory function warrant further investigation.