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Incidence of venous thromboembolism in patients with diffuse large B-cell lymphoma

Ina Hornemann Borg1, Mette Dahl Bendtsen1,2, Martin Bøgsted1,3

  • 1a Department of Hematology , Aalborg University Hospital , Aalborg , Denmark.

Leukemia & Lymphoma
|June 9, 2016
PubMed

Insights

Venous thromboembolism (VTE) affects 11% of diffuse large B-cell lymphoma (DLBCL) patients. Prior VTE, performance status, and disease stage are key risk factors for VTE in DLBCL.

Area of Science:

  • Hematology
  • Oncology
  • Clinical Research

Background:

  • Venous thromboembolism (VTE) is a significant complication in patients diagnosed with diffuse large B-cell lymphoma (DLBCL).
  • Understanding VTE risk factors and diagnostic accuracy is crucial for managing DLBCL patients.

Purpose of the Study:

  • To evaluate the incidence of VTE in a cohort of DLBCL patients.
  • To identify risk factors associated with VTE development in DLBCL.
  • To assess the quality of VTE discharge diagnoses recorded in patient registries.

Main Methods:

  • Retrospective cohort study of DLBCL patients from 2007-2013 at Aalborg University Hospital.
  • Medical record review to identify confirmed VTE events over two years.
  • Cox regression analysis to determine VTE risk factors.
  • Comparison of registry diagnoses with medical records for data quality assessment.

Main Results:

  • Eleven percent of DLBCL patients were diagnosed with VTE.
  • Significant associations found between VTE and prior VTE, performance status, and Ann Arbor stage.
  • The positive predictive value for VTE discharge diagnosis was 85%, with a sensitivity of 53%.

Conclusions:

  • VTE is a common complication in DLBCL patients, influenced by disease stage and patient factors.
  • While registry diagnoses have a high positive predictive value, their sensitivity is limited, highlighting potential underdiagnosis.
  • Improved diagnostic strategies and risk stratification are needed for VTE in DLBCL.

Keywords:
Cancerdischarge diagnosislymphomarisk factorsvenous thromboembolism

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