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Practical experience using transabdominal chorionic villus biopsies taken after 16 weeks' gestation for rapid
J Wolstenholme1, A M Hoogwerf, H Sheridan
1Department of Medical Genetics, Churchill Hospital, Oxford, U.K.
Prenatal Diagnosis
|May 1, 1989
Abstract:
Placental biopsy was performed on 81 patients at greater than 16 weeks' gestation. The major indication for such biopsies was an increased risk of chromosomal abnormality because of either abnormal ultrasound findings or late presentations for advanced maternal age. Six abnormal karyotypes resulting in elective termination were found. The use of rapid karyotyping by this procedure as an alternative to amniocentesis or fetal blood sampling is discussed.