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Microfluidics in systems biology-hype or truly useful?
1School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0100, United States.
Current Opinion in Biotechnology
|June 9, 2016
Summary
Microfluidic technology enhances systems biology research by improving experimental sensitivity and throughput, especially for single-cell and complex biological analyses. When applied correctly, microfluidics significantly advances the understanding and application of biological systems.
Area of Science:
- Systems biology
- Microfluidics
- Biotechnology
Background:
- Systems biology integrates large-scale measurements and modeling to understand complex biological systems.
- Microfluidic technology offers potential for high-throughput experiments in biological research.
- Previous applications have shown microfluidics as a valuable tool for specific systems biology investigations.
Purpose of the Study:
- To review the applications of microfluidics in systems biology.
- To highlight how microfluidics can improve experimental sensitivity and throughput.
- To focus on advancements in single-cell and multi-cellular analyses using microfluidics.
Main Methods:
- Literature review of microfluidic applications in systems biology.
- Analysis of studies focusing on enhanced sensitivity and throughput.
- Examination of microfluidic use in single-cell and complex biological entity analyses.
Main Results:
- Microfluidics can significantly enhance experimental sensitivity and throughput in systems biology.
- Recent developments show promise in single-cell and multi-cellular analyses.
- The utility of microfluidics is dependent on appropriate application within systems biology.
Conclusions:
- Microfluidics is a powerful tool for systems biology when used appropriately.
- It enhances the ability to measure and control biological systems.
- This leads to a deeper understanding and expanded utility of biological systems.
