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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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Selenium status in neonates with connatal infection.
Lennart Wiehe1, Malte Cremer2, Monika Wisniewska1
11Institute for Experimental Endocrinology,Charité Universitätsmedizin Berlin,Suedring 10,Campus Virchow-Klinikum,D-13353 Berlin,Germany.
The British Journal of Nutrition
|June 9, 2016
Summary
Neonatal infection negatively impacts selenium (Se) status. Selenium and selenoprotein P (SePP) are reliable biomarkers for assessing Se status and deficiency risk in newborns.
Area of Science:
- Biochemistry
- Neonatalogy
- Clinical Nutrition
Background:
- Infectious diseases disrupt selenium (Se) metabolism, and low Se status is linked to mortality in critically ill adults.
- The Se status of neonates and the impact of congenital infections remain poorly understood.
- This study investigates the effect of infection on neonatal Se status.
Purpose of the Study:
- To determine if neonatal infection negatively affects selenium (Se) status.
- To evaluate Se and selenoprotein P (SePP) as biomarkers for Se status in neonates.
- To assess the correlation between Se and SePP concentrations in infected and control neonates.
Main Methods:
- An observational case-control study was conducted in a neonatal intensive care unit.
- Plasma samples were collected from 44 neonates (21 infected, 23 controls) on day 1 and day 3.
- Plasma Se and SePP concentrations were measured using X-ray fluorescence and ELISA, respectively.
Main Results:
- A positive correlation was observed between Se and SePP concentrations in both groups.
- Neonates in the infected group exhibited Se concentrations below the adult threshold for Se deficit.
- SePP levels significantly increased during antibiotic therapy in infected neonates, indicating improved hepatic Se metabolism.
Conclusions:
- Selenium (Se) and selenoprotein P (SePP) are effective biomarkers for assessing Se status in neonates.
- These biomarkers can identify neonates at risk of Se deficiency.
- Neonatal infection appears to negatively impact Se status, highlighting the importance of monitoring Se levels.
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