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[Effects of growth hormone treatment on anthropometrics, metabolic risk, and body composition variables in small for

Esther Aurensanz Clemente1, Pilar Samper Villagrasa2, Ariadna Ayerza Casas3

  • 1Departamento de Pediatría, Hospital de Barbastro, Barbastro, Huesca, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|June 9, 2016
PubMed

Insights

Recombinant human growth hormone (rhGH) treatment improves height and weight in small for gestational age (SGA) children. While it enhances body composition, close monitoring for potential insulin resistance is crucial.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Metabolic Disorders

Background:

  • Small for gestational age (SGA) children without catch-up growth may benefit from recombinant human growth hormone (rhGH) therapy.
  • These children are at an increased risk for developing metabolic syndrome, necessitating careful monitoring during treatment.

Purpose of the Study:

  • To evaluate the effects of rhGH treatment on anthropometric, metabolic, and body composition variables in SGA children.
  • To assess the potential risks and benefits of rhGH therapy in this specific patient population.

Main Methods:

  • A cohort of 28 SGA children (mean age 8.79 years) received rhGH treatment over 4 years.
  • Annual evaluations included anthropometric measurements, metabolic risk markers, and body composition analysis.

Main Results:

  • rhGH significantly improved height, weight, and growth rate without altering BMI.
  • Insulinaemia and HOMA index increased, indicating a trend towards insulin resistance.
  • Body composition showed significant increases in lean mass and reductions in fat mass.

Conclusions:

  • rhGH is effective in improving anthropometric parameters and body composition in SGA children.
  • The observed increase in insulin resistance markers warrants close follow-up to determine long-term implications.
  • Further studies are needed to ascertain if these changes persist into adulthood.
Abstract

Keywords:
Body compositionCardiovascular riskComposición corporalGrowth hormoneHormona de crecimientoInsulin resistanceLipoproteinsLipoproteínasPequeño para edad gestacionalResistencia a la insulinaRiesgo cardiovascularSmall for gestational age

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