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Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Arsenite accumulation in the mouse eye.

Norman J Kleiman¹, Adrienne M Quinn², Kara G Fields³

¹a Department of Environmental Health Sciences , Columbia University, Mailman School of Public Health , New York , New York , USA.

Journal of Toxicology and Environmental Health. Part A

|June 9, 2016

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Arsenic (As) in drinking water is a global health risk. This study found higher arsenic levels in mouse eyes and lenses than other organs, suggesting a link to cataract formation.

Area of Science:

Environmental Health
Toxicology
Ophthalmology

Background:

Elevated arsenic (As) in drinking water poses significant global public health risks, linked to various diseases.
Chronic arsenic exposure's effects on the eye remain largely unknown, though oxidative stress is implicated in arsenic pathology and eye diseases like cataracts.

Purpose of the Study:

To investigate arsenic accumulation in ocular tissues following chronic exposure.
To determine if arsenic exposure is a potential contributing factor to eye pathology, specifically cataract formation.

Main Methods:

Mice were exposed to varying concentrations of sodium arsenite (0-250 ppm) in drinking water for 4 weeks or 6 months.
Inductively coupled plasma-mass spectroscopy (ICP-MS) was used to quantify total arsenic concentrations in various tissues, including eyes, lens, liver, kidneys, and brain.

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Main Results:

Arsenic concentrations increased in a dose-dependent manner across all examined organs and tissues.
Ocular tissues, particularly the lens, showed significantly higher arsenic concentrations compared to the liver, lung, heart, spleen, and brain.
Arsenic levels in the eye and lens were comparable to those found in the kidneys.

Conclusions:

The eye and lens accumulate significant levels of arsenic, suggesting arsenic exposure may be a contributing factor to cataract development.
These findings highlight the potential ocular risks associated with endemic arsenic contamination in drinking water sources worldwide.