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Updated: Mar 19, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Lipid-based dispersions of exemestane for improved dissolution rate and intestinal permeability: in vitro and ex vivo
Basanth Babu Eedara1, Suresh Bandari1
1a Department of Pharmaceutics , St. Peter's Institute of Pharmaceutical Sciences , Vidyanagar, Warangal , Telangana , India.
Abstract:
Current study aimed to develop lipid dispersions of poorly water soluble exemestane by employing lipid carriers such as Gelucire 44/14 and TPGS with porous calcium silicate (PCS) as an adsorbent carrier and formulate into a solid dosage form. The lipid dispersions at 1:5 ratio showed the highest solubility and dissolution compared to pure exemestane. Further, the ex vivo intestinal permeation studies showed improved apparent permeability (Papp, cm/s) of exemestane from the lipid dispersions (GLD1:5 1.3 × 10-2 cm/s; TLD1:5 1.8 × 10-2 cm/s) compared to pure exemestane (0.7 × 10-2 cm/s). The optimized lipid dispersions (GLD1:5 and TLD1:5) were evaluated for scalability to develop into capsules.
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