Effectiveness and content analysis of interventions to enhance medication adherence in hypertension: a systematic...

Area of Science:

• Pharmacology and Cardiovascular Health
• Public Health and Patient Adherence

Background:

• Pharmacological treatment of hypertension significantly reduces cardiovascular morbidity and mortality.
• However, medication adherence rates among treated hypertensive patients range from 20% to 50%, compromising treatment efficacy.
• This highlights the need for effective interventions to improve adherence.

Purpose of the Study:

• To systematically review and evaluate the effectiveness of medication adherence interventions specifically for hypertension.
• To explore barriers and facilitators targeted by these interventions.
• To investigate the relationship between targeted theoretical domains and the effect size on blood pressure control.

Main Methods:

• This study is an update to the Cochrane Review by Nieuwlaat et al. (2014).
• A systematic literature search will be conducted, with independent screening and data extraction by two authors.
• Methodological quality will be assessed using the Cochrane Collaboration Risk of Bias Tool, followed by meta-analysis and identification of theoretical factors using the Theoretical Domains Framework.

Main Results:

• This section is to be populated upon completion of the review and meta-analysis.

Conclusions:

• This review will provide quantitative data on the effectiveness of hypertension medication adherence interventions.
• It aims to identify which theoretical domains are most associated with successful interventions.
• The findings will also highlight domains that have been underutilized in intervention development for hypertension management.