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Related Concept Videos

Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
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Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
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Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

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Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
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Laminins are the Adhesive Proteins of Basal Lamina00:55

Laminins are the Adhesive Proteins of Basal Lamina

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Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
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Selectins01:25

Selectins

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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Updated: Mar 19, 2026

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
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Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

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L1CAM: Cell adhesion and more.

Timur R Samatov1, Daniel Wicklein2, Alexander G Tonevitsky3

  • 1SRC Bioclinicum, Ugreshskaya str 2/85, 115088 Moscow, Russia; Moscow State University of Mechanical Engineering, Bolshaya Semenovskaya str 38, 107023 Moscow, Russia.

Progress in Histochemistry and Cytochemistry
|June 9, 2016
PubMed
Summary
This summary is machine-generated.

The L1 cell adhesion molecule (L1CAM) is crucial for nervous system development and shows prognostic value in various cancers. L1CAM presents a promising target for novel anti-cancer therapies.

Keywords:
CancerCell adhesionIg-like domainsL1CAM

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Area of Science:

  • Neuroscience
  • Oncology
  • Molecular Biology

Background:

  • L1 cell adhesion molecule (L1CAM) is an immunoglobulin superfamily member.
  • Initially identified for its role in nervous system development.
  • Emerging evidence highlights L1CAM's significance in cancer biology.

Purpose of the Study:

  • To provide a comprehensive overview of L1CAM.
  • To discuss L1CAM's structure, function, and expression.
  • To explore L1CAM's role in cancer and its therapeutic potential.

Main Methods:

  • Literature review of existing data on L1CAM.
  • Analysis of L1CAM's involvement in oncogenesis.
  • Evaluation of L1CAM as a therapeutic target.

Main Results:

  • L1CAM plays a role in nervous system development.
  • L1CAM expression is linked to prognosis in various cancers.
  • L1CAM demonstrates potential as an anti-cancer therapeutic target.

Conclusions:

  • L1CAM is a multifaceted molecule with implications beyond neurodevelopment.
  • Understanding L1CAM's function in cancer is critical for therapeutic development.
  • Targeting L1CAM offers a promising avenue for cancer treatment strategies.