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Published on: October 24, 2018
BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database
Galina Y Zheleznyakova1,2, Hao Cao3, Helgi B Schiöth3
1Department of Neuroscience, Uppsala University, Husargatan 3, BMC, 75124, Uppsala, Sweden. galina.zheleznyakova@ki.se.
Abstract:
Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and function and it is well established that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders. Recently, numerous studies have associated the DNA methylation level of BDNF promoters with certain psychiatric phenotypes. In this review, we summarize data from current literature as well as from our own analysis with respect to the correlation of BDNF methylation changes with psychiatric disorders and address questions about whether DNA methylation related to the BDNF can be useful as biomarker for specific neuropsychiatric disorders.
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