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Updated: Mar 19, 2026
09:04
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
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VEGF receptor signal transduction - A brief update
1Uppsala University, Dept. Immunology, Genetics and Pathology, Rudbeck Laboratory, Dag Hammarskjöldsv 20, 751 85 Uppsala, Sweden.
Vascular Pharmacology
|June 9, 2016
Summary
Vascular endothelial growth factor (VEGF) signaling via its receptors is vital for immune cells and blood/lymphatic vessels in health and disease, especially cancer. This review focuses on in vivo data of VEGF receptor signaling pathways.
Area of Science:
- Molecular Biology
- Cell Biology
- Oncology
Background:
- Vascular endothelial growth factor (VEGF) is a key signaling protein.
- VEGF exerts its functions through receptor tyrosine kinases: VEGF receptor-1, -2, and -3.
- These receptors are critical for monocytes/macrophages, blood vascular endothelial cells, and lymphatic endothelial cells.
Purpose of the Study:
- To review the current understanding of VEGF receptor signaling.
- To emphasize the in vivo data related to VEGF receptor signaling pathways.
Main Methods:
- Literature review of studies focusing on in vivo data.
- Synthesis of current knowledge on VEGF receptor signaling.
Main Results:
- VEGF receptor signaling is crucial in both physiological conditions and various pathologies.
- Cancer is a notable pathology where VEGF signaling plays a significant role.
- In vivo data provides critical insights into the complex roles of VEGF receptors.
Conclusions:
- VEGF receptor signaling is a fundamental biological process with broad implications.
- Understanding VEGF receptor signaling in vivo is essential for developing therapeutic strategies, particularly in oncology.
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