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Related Experiment Video

Updated: Mar 19, 2026

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

Microenvironmental Control of Adipocyte Fate and Function.

Benjamin D Pope¹, Curtis R Warren², Kevin Kit Parker³

¹Disease Biophysics Group, Harvard Stem Cell Institute, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA; Harvard Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.

Trends in Cell Biology

|June 9, 2016

Summary

The specialized microenvironment around fat cells (adipocytes) is crucial for their function. Disrupted remodeling of this environment in obesity can drive diseases like metabolic syndrome and cancer.

Keywords:

adipose development biomechanics extracellular matrix metabolic disease signal transduction tissue engineering.

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Last Updated: Mar 19, 2026

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

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Published on: May 19, 2023

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

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Published on: June 3, 2016

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

Area of Science:

Cell biology
Physiology
Endocrinology

Background:

Tissue-specific microenvironments significantly impact cell structure and function.
Adipocytes rely on specialized niches for metabolic and endocrine roles.
Microenvironmental remodeling is essential for adipose tissue expansion and integrity.

Purpose of the Study:

To highlight the regulatory role of adipocyte microenvironments in health and disease.
To underscore the importance of understanding adipose tissue niches.
To emphasize the connection between disrupted microenvironments and obesity-related diseases.

Main Methods:

Review of existing literature on adipocyte biology and microenvironments.
Analysis of the impact of tissue remodeling on adipocyte function.
Correlation of disrupted adipose microenvironments with disease progression.

Main Results:

Adipocyte function is intrinsically linked to its surrounding microenvironment.
Obesity-induced disruption of adipose tissue remodeling contributes to metabolic dysfunction.
Altered microenvironments are implicated in the development of metabolic syndrome and cancer.

Conclusions:

Adipocyte microenvironments are critical regulators of metabolic health.
Understanding adipose tissue niche dynamics is key to addressing obesity-related diseases.
Further research into in vitro models is needed to study these interactions.