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Biodegradable microparticles for delivery of polypeptides and proteins
G Spenlehauer1, F Spenlehauer-Bonthonneau, C Thies
1Biological Transport Laboratory, Washington University, St. Louis, Missouri 63130.
Progress in Clinical and Biological Research
|January 1, 1989
Abstract:
Interest in the immobilization of polypeptides has caused various workers to develop methods for fabricating polypeptide-loaded microparticles from biodegradable polymers. A range of physical phenomena is used to form these microparticles. Thus far, all of the processes utilize a solvent or solvent combination. Selection of these solvents in such a manner that particles free of potentially harmful residual or entrapped material can be produced has not been discussed, but should receive full attention.