Lisinopril-Induced Alopecia: A Case Report.

Area of Science:

• Cardiology
• Pharmacology
• Dermatology

Background:

• Angiotensin-converting enzyme (ACE) inhibitors are primary treatments for heart failure.
• Common adverse effects include hyperkalemia and elevated serum creatinine.
• Alopecia is a rare but reported side effect of some ACE inhibitors.

Observation:

• A 53-year-old male patient developed new-onset alopecia.
• The patient was undergoing treatment for heart failure with lisinopril.
• Alopecia was suspected to be a side effect of lisinopril.

Findings:

• Lisinopril was discontinued and replaced with losartan potassium (an angiotensin receptor blocker).
• The patient's alopecia resolved within 4 weeks of switching medications.
• The Naranjo Adverse Drug Reaction Probability Scale indicated a probable link between lisinopril and alopecia (score of 6).

Implications:

• This case highlights lisinopril as a potential cause of unexplained alopecia.
• Clinicians should consider lisinopril-induced alopecia in patients presenting with hair loss.
• Early identification and discontinuation of the offending agent can lead to successful resolution.