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Updated: Mar 19, 2026
Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
Published on: June 14, 2017
Searching the literature for proteins facilitates the identification of biological processes, if advanced methods of
Johann Bauer1, Markus Bussen2, Petra Wise3
1a Informationsvermittlung , Max-Planck Institute for Biochemistry , Martinsried , Germany.
Background:
More than one hundred reports were published about the characterization of cells from malignant and healthy tissues, as well as of endothelial cells and stem cells exposed to microgravity conditions.
Methods:
We retrieved publications about microgravity related studies on each type of cells, extracted the proteins mentioned therein and analyzed them aiming to identify biological processes affected by microgravity culture conditions.
Results:
The analysis revealed 66 different biological processes, 19 of them were always detected when papers about the four types of cells were analyzed.
Conclusion:
Since a response to the removal of gravity is common to the different cell types, some of the 19 biological processes could play a role in cellular adaption to microgravity. Applying computer programs, to extract and analyze proteins and genes mentioned in publications becomes essential for scientists interested to get an overview of the rapidly growing fields of gravitational biology and space medicine.
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