Related Experiment Video

Updated: Aug 17, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

Comparison of the dissolution behaviour of tablets containing the drug in a polyethyleneglycol solid dispersion with

R Kinget

    Pharmaceutica Acta Helvetiae
    |January 1, 1989
    PubMed

    More Related Videos

    Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs08:18

    Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

    Published on: July 27, 2022

    Formation of Dispersible Taohong Siwu Tablets05:44

    Formation of Dispersible Taohong Siwu Tablets

    Published on: February 3, 2023

    Related Concept Videos

    Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

    Factors Influencing Drug Absorption: Pharmaceutical Parameters

    Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
    Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

    Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

    Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
    Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
    In Vitro Drug Dissolution: Compendial Testing Models I01:13

    In Vitro Drug Dissolution: Compendial Testing Models I

    Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
    In Vitro Drug Dissolution: Compendial Testing Models II01:09

    In Vitro Drug Dissolution: Compendial Testing Models II

    Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
    Drug Dissolution: Requirements and Profile Comparison01:14

    Drug Dissolution: Requirements and Profile Comparison

    The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...
    Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

    Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

    Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...