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Related Experiment Video

Updated: Mar 19, 2026

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

Cilia Train Spotting.

Stefanie Kuhns¹, Oliver E Blacque¹

¹School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland.

Developmental Cell

|June 9, 2016

Summary

Intraflagellar transport trains move along ciliary microtubules to form cilia. These trains avoid collisions by traveling on distinct A- and B-tubules within the cilium.

Area of Science:

Cell Biology
Structural Biology

Background:

Cilium formation relies on intraflagellar transport (IFT) trains.
IFT trains move bidirectionally along ciliary microtubules.

Purpose of the Study:

To determine the ultrastructure of anterograde and retrograde IFT trains.
To understand how IFT trains avoid collisions within cilia.

Main Methods:

Correlative light and electron microscopy (CLEM)
High-resolution imaging of ciliary ultrastructure in algae

Main Results:

IFT trains exhibit distinct ultrastructural features for anterograde and retrograde movement.
Anterograde trains utilize B-tubules, while retrograde trains utilize A-tubules.

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Last Updated: Mar 19, 2026

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

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Published on: October 13, 2019

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Published on: October 6, 2019

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This spatial segregation prevents collisions between oppositely directed IFT trains.

Conclusions:

IFT trains segregate onto specific A- and B-tubules to ensure efficient and collision-free transport.
Understanding IFT train organization provides insights into ciliary assembly and function.