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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Ethics in Research01:56

Ethics in Research

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Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
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Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

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Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
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Study Designs in Epidemiology01:20

Study Designs in Epidemiology

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Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
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Specialized Care Centers and Settings-I01:30

Specialized Care Centers and Settings-I

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Specialized care settings or centers are situated in convenient locations within the community and offer care to a specific group or population. They consist of daycare facilities, mental health facilities, rural health facilities, educational institutions, industries, shelters for the homeless, and rehabilitation facilities.
Daycare centers
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Eulogy for the clinical research center.

David G Nathan, David M Nathan

    The Journal of Clinical Investigation
    |June 9, 2016
    PubMed
    Summary

    The General Clinical Research Center (GCRC) program, a vital hub for medical research and training for over 50 years, has lost federal funding. This decision impacts clinical investigation and medical advancements, marking a significant loss for science.

    Area of Science:

    • Medical research infrastructure
    • Clinical translational science
    • Human subjects research

    Background:

    • The extramural General Clinical Research Center (GCRC) program provided critical federally funded laboratory support for over 50 years.
    • GCRCs were instrumental in training clinical investigators and conducting groundbreaking human studies.
    • Funding for GCRCs was initially managed by the National Center for Research Resources (NIH) and later by the Clinical Translational Science Award (CTSA) program.

    Purpose of the Study:

    • To review the history and contributions of the General Clinical Research Center (GCRC) program.
    • To discuss the recent cessation of funding for GCRCs by the National Center for Advancing Translation Sciences (NCATS).
    • To commemorate the legacy and impact of GCRCs on medical science and clinical care.

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    Main Methods:

    • Historical review of the GCRC program.
    • Analysis of GCRC contributions to medical advancement.
    • Examination of the funding changes and their implications.

    Main Results:

    • GCRCs have a rich history spanning over 50 years, significantly advancing medical science.
    • These centers provided essential training grounds and support for clinical investigators.
    • NCATS has recently ceased funding for GCRCs, leading to their closure.

    Conclusions:

    • The closure of GCRCs represents a significant loss for clinical research and medical progress.
    • The program's legacy includes numerous advancements in medical science and improved patient care.
    • The lack of discussion preceding the funding cessation is noted with regret.