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A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Inflammatory Response Using Different Lipid Parenteral Nutrition Formulas in Children After Hematopoietic Stem Cell
María Auxiliadora Baena-Gómez1, María José de la Torre-Aguilar1, Concepción María Aguilera-García2
1a Department of Paediatrics , Unit of Paediatric Research, Reina Sofia University Hospital, Maimónides Institute of Biomedical Research of Córdoba (IMIBIC), University of Córdoba , Córdoba , Spain.
Insights
Omega-3 fatty acids (n-3 FA) in parenteral nutrition (PN) did not alter inflammatory markers in children post-hematopoietic stem cell transplantation (HSCT) within 10 days. However, prolonged PN with fish oil-based lipid emulsions (LE) may reduce specific inflammatory cytokines.
Area of Science:
- Nutrition and Immunology
- Hematology and Transplantation
Background:
- Nutritional support is crucial for hematopoietic stem cell transplantation (HSCT) patients.
- Omega-3 fatty acids (n-3 FA) in parenteral nutrition (PN) may influence inflammatory responses.
Purpose of the Study:
- To compare plasma cytokine levels in pediatric HSCT patients receiving PN with n-3 FA-containing lipid emulsions (LE) versus soybean oil-based LE.
Main Methods:
- A randomized, double-blind, controlled trial involving 14 pediatric HSCT patients.
- Patients received either fish oil or soybean oil LE in PN.
- Plasma cytokines (IL-1β, IL-2, IL-6, IL-8, IL-10, TNF-α) were analyzed at baseline, Day 10, and post-PN.
Main Results:
- No significant changes in interleukin levels were observed after 10 days of PN between groups or time points.
- In patients requiring PN >21 days, IL-10 and TNF-α levels were significantly lower in the fish oil LE group (P ≤ 0.05).
Conclusions:
- PN with fish oil or soybean oil LE for at least 10 days does not induce inflammatory changes in HSCT patients.
- Extended PN using fish oil-based LE may potentially modulate the inflammatory response in this population.
Abstract:
Nutritional support is an integral part of the supportive care of hematopoietic stem cell transplantation (HSCT) patients. Omega-3 fatty acids (n-3 FA) emulsions in parenteral nutrition (PN) may modify the inflammatory response. The purpose of this study is to compare plasma cytokine levels in children after HSCT using an n-3 FA-containing lipid emulsion (LE) and a soybean oil-based formulation in PN. A randomized double-blind controlled trial was conducted on 14 children following HSCT. Children were randomized to receive either a fish oil or a soybean oil LE. Blood samples were drawn at baseline, on Day 10 and after completion of PN to analyze plasma interleukin 1 beta (IL-1β), 2 (IL-2), 6 (IL-6), 8 (IL-8), 10 (IL-10), and tumor necrosis factor alpha (TNF-α). After 10 days of PN, there were no significant changes in interleukins levels when comparing the two groups or time points (baseline vs. Day 10 of PN). In children requiring PN >21 days, IL-10 and TNF-α levels (P ≤ 0.05) were lower in the fish-oil-containing LE group. Fish oil- and soybean oil-supplemented PN administered for at least 10 days does not cause inflammatory changes. Prolonged PN based on fish oil LE may modulate the inflammatory response.
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