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Related Experiment Video

Updated: Mar 19, 2026

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

Metabolic rewiring in melanoma.

B I Ratnikov¹, D A Scott¹, A L Osterman¹

¹Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla CA, USA.

|June 9, 2016

Summary

Cancer cells rewire metabolism to survive in tumors. Melanoma

Area of Science:

Oncology
Cancer Metabolism
Molecular Biology

Background:

Cancer cells adapt to tumor microenvironments via metabolic rewiring.
Aerobic glycolysis and glutamine metabolism are key adaptations.
Specific genetic alterations dictate metabolic profiles in cancers.

Purpose of the Study:

To discuss metabolic alterations in melanoma development.
To explore how these metabolic changes affect therapy response.

Main Methods:

Review of oncogene-driven metabolic rewiring.
Focus on Mitogen-Activated Protein Kinase (MAPK) pathway in melanoma.
Analysis of factors controlling central carbon metabolism balance.

Main Results:

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Last Updated: Mar 19, 2026

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

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Published on: August 27, 2021

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Melanoma exhibits specific metabolic alterations driven by MAPK pathway activation (BRAF/NRAS).
Factors like HIF1α, Myc, and MITF influence metabolic balance.
Metabolic rewiring is crucial for melanoma proliferation and therapeutic response.

Conclusions:

Metabolic alterations are fundamental to melanoma pathogenesis.
Understanding these metabolic changes is vital for developing effective melanoma therapies.