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Related Concept Videos

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Intraperitoneal-Free Cancer Cells Represent a Major Prognostic Factor in Colorectal Peritoneal Carcinomatosis.

B Trilling1, E Cotte, D Vaudoyer

  • 11 Clinique de Chirurgie Viscérale et de l'Urgence, Grenoble Alpes, France 2 Département de Chirurgie Générale, Digestive et Cancérologique, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre Bénite, France 3 EMR 37-38 Université Lyon1, Lyon, France 4 Service d'Anatomie et Cytologie Pathologiques, CHU Lyon-Sud, Lyon, France 5 Centre de Pathologie Est, CHU Edouard Herriot, Lyon, France 6 Hospices Civils de Lyon, Pole IMER, Unité de Recherche Clinique, Lyon, France.

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Intraperitoneal-free cancer cells are a significant prognostic indicator for colorectal peritoneal carcinomatosis. Their presence impacts survival, suggesting tailored treatment strategies for better patient outcomes.

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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastroenterology

Background:

  • Intraperitoneal-free cancer cells (IFCCs) are established prognostic markers in gastric and ovarian cancers.
  • Their prognostic value in colorectal cancer (CRC) with peritoneal carcinomatosis (PC) is less understood and debated.

Purpose of the Study:

  • To investigate the prognostic role of IFCCs in patients with CRC undergoing complete cytoreductive surgery for PC.
  • To assess the impact of IFCCs on overall survival and treatment strategies.

Main Methods:

  • Analysis of a prospectively maintained database of 162 patients with CRC-PC treated between 1991 and 2012.
  • Evaluation of peritoneal cytology for the presence of IFCCs.
  • Multivariate analysis incorporating Peritoneal Carcinomatosis Index (PCI) and IFCC status.

Main Results:

  • 38.5% of patients (n=38) had positive IFCCs.
  • Median overall survival was significantly lower for patients with positive IFCCs (19 months) compared to those with negative IFCCs (44 months) (p=0.018).
  • Positive IFCCs and higher PCI were independent predictors of poorer overall survival.

Conclusions:

  • IFCCs are a strong prognostic factor in CRC-PC patients treated with curative intent surgery.
  • The detection of IFCCs warrants consideration of intensified treatment approaches, including intraperitoneal therapies.
  • Further research may refine treatment protocols based on IFCC status.