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Related Experiment Video

Updated: Mar 19, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable shear-thinning nanoengineered hydrogels for stem cell delivery.

Ashish Thakur1, Manish K Jaiswal1, Charles W Peak1

  • 1Department of Biomedical Engineering, Texas A&M University, College Station, TX-77843, USA. gaharwar@tamu.edu.

Nanoscale
|June 9, 2016
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Summary

Injectable hydrogels reinforced with 2D nanosilicates improve cell delivery. These shear-thinning nanocomposite hydrogels enhance mechanical properties and cell viability for tissue regeneration.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Regenerative Medicine

Background:

  • Injectable hydrogels are crucial for cell encapsulation and delivery, protecting cells from shear forces.
  • Reinforcing polymer networks with 2D nanomaterials creates shear-thinning hydrogels with enhanced properties.
  • 2D nanomaterials offer unique anisotropy and strong polymer interactions.

Purpose of the Study:

  • To develop 2D nanosilicate-reinforced kappa-carrageenan (κCA) hydrogels for injectable cell delivery.
  • To investigate the impact of 2D nanosilicates on the properties of photocrosslinked kappa-carrageenan (MκCA) hydrogels.
  • To evaluate the suitability of these nanoengineered hydrogels for human mesenchymal stem cell (hMSC) delivery.

Main Methods:

  • Chemically modified kappa-carrageenan (MκCA) was synthesized by introducing photocrosslinkable methacrylate groups.
  • MκCA hydrogels were reinforced with 2D nanosilicates to form nanocomposite hydrogels.
  • The shear-thinning behavior, mechanical properties, and physiological stability of the nanocomposite hydrogels were characterized.
  • Human mesenchymal stem cells (hMSCs) were encapsulated and their viability and morphology post-injection were assessed.

Main Results:

  • The 2D nanosilicate reinforcement imparted shear-thinning characteristics to the MκCA hydrogels.
  • Enhanced mechanical stiffness, elastomeric properties, and physiological stability were observed in the nanocomposite hydrogels.
  • Encapsulated hMSCs demonstrated high viability and maintained a circular morphology after injection.
  • The hydrogels exhibited suitable properties for cell delivery applications.

Conclusions:

  • 2D nanosilicate-reinforced MκCA hydrogels offer improved injectability and mechanical integrity for cell delivery.
  • These nanoengineered hydrogels support high cell viability and are promising for cartilage tissue regeneration.
  • The developed shear-thinning hydrogels are suitable for 3D bioprinting and advanced regenerative medicine applications.