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Updated: Mar 19, 2026
Alternative In Vitro Methods for the Determination of Viral Capsid Structural Integrity
Published on: November 16, 2017
Application of Laser Correlation Spectroscopy for Measuring Virus Size
V N Nikiforov1, S E Vinogradov2, A V Ivanov2
1Physical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. nvn@lt.phys.msu.ru.
Abstract:
Dynamic light scattering method or laser correlation spectroscopy was applied to evaluation of the size of viruses. We measured correlation functions of the light scattered by human immunodeficiency viruses (HIV) and hepatitis A viruses (HAV) and found that size of HIV-1 (subtype A and B) and HAV virions were 104 nm and 28 nm, respectively. Comparison of these findings with electron microscopy data for fixed samples of the same viruses showed good agreement of the results.
