Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Overview01:20

Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Overview

21.2K
The Fischer esterification reaction was developed by the German chemist Emil Fischer in 1895. It is a condensation reaction between carboxylic acids and alcohols in an acidic medium to give esters and water.
21.2K
Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Mechanism01:13

Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Mechanism

10.4K
Carboxylic acids react with alcohols to yield esters via an acid-catalyzed condensation reaction called Fischer esterification. This is a nucleophilic acyl substitution reaction that proceeds via a tetrahedral intermediate, where a water molecule is eliminated as the leaving group.
10.4K
Alkylation of β-Diester Enolates: Malonic Ester Synthesis01:14

Alkylation of β-Diester Enolates: Malonic Ester Synthesis

4.3K
Malonic ester synthesis is a method to obtain α substituted carboxylic acids from ꞵ-diesters such as diethyl malonate and alkyl halides.
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

King's College Hospital's A&E department.

BMJ (Clinical research ed.)·1992
Same author

Garage door injuries in children.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·1992
Same author

Microinvasive carcinoma of the cervix.

Cancer·1992
Same author

Environmental and familial contributions to insulin levels and change in insulin levels in middle-aged women.

JAMA·1992
Same author

Pulmonary surfactant secretion is regulated by the physical state of extracellular phosphatidylcholine.

The Journal of biological chemistry·1992
Same author

Correlating CBC profile and infectious outcome. A study of febrile infants evaluated for sepsis.

Clinical pediatrics·1992

Related Experiment Video

Updated: Mar 19, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.6K

Fumaric acid esters for psoriasis: a systematic review.

D Smith1

  • 1Department of Dermatology, University Hospital Limerick, Limerick, Ireland. smithd1@tcd.ie.

Irish Journal of Medical Science
|June 9, 2016
PubMed
Summary

Fumaric acid esters (FAE) are a safe and effective treatment for moderate to severe psoriasis. Close monitoring of blood parameters ensures safe use, making FAE a promising option for patients unresponsive to other therapies.

Keywords:
FumadermFumaric acid estersPsoriasis

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

995

Related Experiment Videos

Last Updated: Mar 19, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.6K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

995

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Psoriasis is a chronic skin condition with significant morbidity and mortality.
  • Current systemic treatments for psoriasis have potential side effects.
  • Fumaric acid esters (FAE) are a first-line treatment in Germany but used off-label in Ireland.

Purpose of the Study:

  • To systematically review the efficacy and safety of FAE for moderate to severe psoriasis in adults.
  • To evaluate available literature on FAE treatment outcomes in psoriasis management.

Main Methods:

  • Systematic literature review of PubMed, TRIP, Embase, and Cochrane databases.
  • Included randomized controlled trials, cohort studies, and case studies of adult psoriasis patients treated with FAE.
  • Excluded studies on mild psoriasis, children, or concurrent systemic treatments.

Main Results:

  • 19 articles reviewed, including RCTs, cohort, and case studies.
  • FAE demonstrated safety and efficacy in managing moderate to severe psoriasis.
  • Common side effects (GI issues, lymphocytopenia, eosinophilia) are manageable; renal/hepatic effects are rare and reversible.

Conclusions:

  • FAE is a promising treatment for moderate to severe psoriasis, especially for patients intolerant to other therapies.
  • Close monitoring of blood parameters, per EMA guidelines, ensures safe clinical use.
  • Licensing FAE in Ireland would expand treatment options for psoriasis patients.