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Dual 24-hour feeding response to 2DG in rats: daytime increase and nighttime decrease.

C I Thompson1, R L Fleming, K A Franken

  • 1Department of Psychology, Wabash College, Crawfordsville, IN 47933.

Physiology & Behavior
|January 1, 1989
PubMed
Summary
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The glucose analog 2-deoxy-D-glucose (2DG) influences rat feeding behavior, increasing daytime food intake and decreasing nighttime intake. These dual effects persist for 18-24 hours and depend on the light:dark cycle.

Area of Science:

  • Neuroscience
  • Behavioral Endocrinology
  • Pharmacology

Background:

  • The glucose analog 2-deoxy-D-glucose (2DG) is used to study glucose metabolism and its effects on physiological processes.
  • Previous research suggests 2DG can influence feeding behavior, but its long-term and context-dependent effects are not fully understood.

Purpose of the Study:

  • To investigate the persistent and opposing effects of 2DG on food intake in rats.
  • To determine if these effects are influenced by the timing of administration relative to the light:dark cycle.

Main Methods:

  • Thirty-six rats received intraperitoneal injections of 2DG (0, 250, or 500 mg/kg) at light and dark onset over 7-day intervals.
  • Food intake was monitored for 24 hours post-injection.
  • A second study involved sequential injections of 2DG or saline at different times of day, with food withheld prior to testing.

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Main Results:

  • A dose of 500 mg/kg 2DG increased food intake during daylight hours, irrespective of injection timing (morning or evening).
  • The same dose consistently reduced food intake during the first 6 hours of darkness.
  • In a sequential injection paradigm, 2DG demonstrated opposing effects: decreasing nighttime intake after a morning injection and increasing daytime intake after an evening injection.

Conclusions:

  • 2DG (500 mg/kg) exerts independent, opposing alimentary effects that last 18-24 hours.
  • These effects are not explained by malaise or simple compensatory mechanisms.
  • The direction of 2DG's influence on feeding behavior is dependent on the phase of the light:dark cycle.