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Brain Structures Implicated in Inflammation-Associated Depression.

Neil A Harrison1,2,3

  • 1Department of Neuroscience, Brighton & Sussex Medical School, University of Sussex, Brighton, BN1 9RR, UK. n.harrison@bsms.ac.uk.

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Summary
This summary is machine-generated.

Systemic inflammation causes sickness behaviors that mimic major depressive disorder (MDD). This review syntheses neuroimaging findings, revealing shared and distinct neural circuits between inflammation and MDD.

Keywords:
AmygdalaCytokineDepressionInflammationInsulaInterferonMRIMicrogliaPETVentral striatumfMRI

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Immunology

Background:

  • Systemic inflammation triggers sickness behaviors affecting mood, motivation, and cognition.
  • Severe or chronic inflammation can present symptoms indistinguishable from major depressive disorder (MDD).

Purpose of the Study:

  • To synthesize neuroimaging research on inflammation-induced sickness behaviors.
  • To compare neural circuitry commonalities and differences between sickness behaviors and MDD.
  • To identify future research directions in this interdisciplinary field.

Main Methods:

  • Review of human and rodent neuroimaging studies.
  • Analysis of experimental inflammatory challenges.
  • Comparative analysis of neural circuitries in inflammation and MDD.

Main Results:

  • Neuroimaging clarifies neural circuits underlying sickness behaviors.
  • Remarkable overlap exists between neural abnormalities in sickness behaviors and MDD.
  • Specific areas of convergence and divergence in neural circuitry are identified.

Conclusions:

  • Inflammation-induced sickness behaviors share significant neural circuit underpinnings with MDD.
  • Understanding these overlaps offers insights into MDD pathophysiology.
  • Further research is needed to fully elucidate the relationship and guide therapeutic strategies.