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Intralipid in acute caffeine intoxication: a case report.
Luisa Muraro1, Laura Longo2, Federico Geraldini2
1Anesthesia and Intensive Care Unit (UOC), Hospital of Padova, 2, Giustiniani St., 35128, Padua, Italy. mdluigia@gmail.com.
Journal of Anesthesia
|June 9, 2016
Summary
A severe caffeine overdose was successfully treated with Intralipid, a lipid emulsion. This case highlights Intralipid
Area of Science:
- Toxicology
- Emergency Medicine
- Cardiology
Background:
- Caffeine is a widely consumed stimulant.
- Caffeine overdose can lead to life-threatening complications.
- Standard resuscitation measures may be insufficient for severe caffeine toxicity.
Observation:
- A 19-year-old male ingested 40g of caffeine, resulting in agitation, seizures, and ventricular fibrillation.
- Despite advanced life support, including defibrillation and medications, the patient remained hemodynamically unstable.
- Intravenous lipid emulsion (Intralipid) was administered due to refractory cardiac instability.
Findings:
- Intralipid infusion successfully stabilized the patient's cardiovascular system.
- Plasma caffeine levels remained supra-lethal (>120 mg/L) after lipid emulsion, indicating its effectiveness.
- The patient survived without neurological complications.
Implications:
- Intravenous lipid emulsion is a potentially life-saving treatment for severe caffeine overdose.
- Intralipid may act as a "scavenging mechanism" for lipophilic toxins.
- This case expands the use of Intralipid beyond local anesthetic systemic toxicity.
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