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Adaptation and bursting in neocortical neurones may be controlled by a single fast potassium conductance
N J Berman1, P C Bush, R J Douglas
1MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford.
Abstract:
We have used computer simulation of a model neurone and in vitro intracellular recording to demonstrate that the adaptation of repetitive discharge in neocortical neurones can be explained by a fast potassium current whose inactivation is retarded by intracellular calcium. The maximum amplitude of this current determines whether the neurone will discharge in regular or burst mode.