Related Experiment Video

Updated: Mar 19, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

10.0K

Association of Matrix Metalloproteinase-9 (MMP9) Variants with Primary Angle Closure and Primary Angle Closure

Xueli Chen1,2, Yuhong Chen1, Janey L Wiggs2

  • 1Department of Ophthalmology & Vision Science, Eye & Ear Nose Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Plos One
|June 9, 2016
PubMed

Insights

Genetic variants in matrix metalloproteinase-9 (MMP9) were investigated for their role in primary angle closure glaucoma (PACG). This large study found no significant association between common MMP9 variants and PACG in the Chinese population.

Area of Science:

  • Ophthalmology
  • Genetics
  • Glaucoma Research

Background:

  • Primary angle closure glaucoma (PACG) is characterized by shorter axial length, potentially linked to matrix metalloproteinase-9 (MMP9) activity and extracellular matrix (ECM) remodeling during ocular development.
  • Understanding the genetic basis of PACG is crucial for developing targeted therapies and improving patient outcomes.

Purpose of the Study:

  • To investigate the association between common variants in the MMP9 gene and the risk of PACG in a Chinese cohort.
  • To evaluate previously reported associations of MMP9 variants with PACG using meta-analysis.

Main Methods:

  • Genotyping of six tag single nucleotide polymorphisms (SNPs) in the MMP9 gene was performed in 1,030 cases (572 PACG, 458 primary angle closure [PAC]) and 499 controls.
  • Meta-analysis was conducted, combining the current study's data with previously published studies, including both Chinese and non-Chinese populations.

Main Results:

  • None of the six genotyped MMP9 SNPs showed a significant association with PAC/PACG in the Chinese cohort.
  • Meta-analysis of Chinese datasets did not replicate previously reported associations for rs17576 and rs3918249.
  • A nominal association was observed for rs17577 with PAC/PACG in an overall meta-analysis (ORs = 1.26, Pc = 0.05), but this was not consistently significant across all analyses.

Conclusions:

  • The study did not find significant evidence supporting a role for common MMP9 variants in PACG development within the Chinese population.
  • Heterogeneity between Chinese and non-Chinese datasets limited the scope of overall meta-analyses.
  • Further research is warranted to fully elucidate the potential contribution of MMP9 genetic variants to PACG pathogenesis.

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

2.0K
A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice09:26

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

Published on: March 23, 2016

20.8K

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
9.6K
Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
3.6K
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
866