Related Experiment Video For Acinar cell carcinoma
Updated: Mar 19, 2026

Pancreatic Tissue Dissection to Isolate Viable Single Cells
Published on: May 26, 2023
Pancreatic-type Acinar Cell Carcinoma of the Stomach Included in Multiple Primary Carcinomas
Yoshikuni Yonenaga1, Manabu Kurosawa2, Masahiro Mise3
1Department of Surgery, Nagahama City Hospital, Nagahama, Japan yoney@m.ehime-u.ac.jp.
Background/Aim:
Pancreatic-type acinar cell carcinoma (ACC) in the stomach is extraordinarily rare. We pathologically examined two cases with multiple primary carcinomas, including gastric tumors.
Patients And Methods:
Gastric cancer specimens were examined by immunostaining and electron microscopy.
Results:
Both cases had cancer cells with acinar patterns, resembling pancreatic ACC. The cancer cells in the first case were positive for exocrine markers, including chymotrypsin, lipase and alpha-1 antichymotrypsin (ACT), as well as neuroendocrine markers, including chromogranin A and synaptophysin. The cancer cells in the second case were positive for chymotrypsin and alpha-1 ACT, while being slightly positive for chromogranin A and synaptophysin. Ultrastructurally, cancer cells contained zymogen granules in both cases. The final diagnosis was pancreatic mixed acinar-neuroendocrine carcinoma and pure pancreatic ACC, respectively.
Conclusion:
We confirmed two cases with gastric pancreatic-type ACC included in multiple primary carcinomas. This type of double cancer has not been reported previously.
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